| | Visitado | | | Visitante | Data | Hora |  | | Rubin | 0 | 1 | Olympiakos | 14-02 | 11:00 | | Sp. Braga | 0 | 2 | Besiktas | 14-02 | 17:30 | | Lok. Moscovo | 2 | 1 | At. Bilbau | 16-02 | 17:00 | | Ajax | 0 | 2 | Man. United | 16-02 | 18:00 | | Salzburg | 0 | 4 | Metalist Kharkiv | 16-02 | 18:00 | | AZ Alkmaar | 1 | 0 | Anderlecht | 16-02 | 18:00 | | Lazio | 1 | 3 | At. Madrid | 16-02 | 18:00 | | Plzen | 1 | 1 | Schalke 04 | 16-02 | 18:00 | | Légia Varsóvia | 2 | 2 | Sporting | 16-02 | 18:00 | | FC Porto | 1 | 2 | Manchester City | 16-02 | 20:05 | | Stoke City | 0 | 1 | Valência | 16-02 | 20:05 | | Steaua Bucareste | 0 | 1 | Twente | 16-02 | 20:05 | | Wisla Cracóvia | 1 | 1 | St. Liége | 16-02 | 20:05 | | Udinese | 0 | 0 | PAOK Salónica | 16-02 | 20:05 | | Trabzonspor | 1 | 2 | PSV Eindhoven | 16-02 | 20:05 | | Hannover | 2 | 1 | Brugge | 16-02 | 20:05 | |
| | | | Visitado | | | Visitante | Data | Hora | | | Manchester City | 4 | 0 | FC Porto | 22-02 | 17:00 | | At. Bilbau | 1 | 0 | Lok. Moscovo | 23-02 | 18:00 | | Valência | 1 | 0 | Stoke City | 23-02 | 18:00 | | Twente | 1 | 0 | Steaua Bucareste | 23-02 | 18:00 | | St. Liége | 0 | 0 | Wisla Cracóvia | 23-02 | 18:00 | | PAOK Salónica | 0 | 3 | Udinese | 23-02 | 18:00 | | PSV Eindhoven | 4 | 1 | Trabzonspor | 23-02 | 18:00 | | Brugge | 0 | 1 | Hannover | 23-02 | 18:00 | | Man. United | 1 | 2 | Ajax | 23-02 | 20:05 | | Metalist Kharkiv | 4 | 1 | Salzburg | 23-02 | 20:05 | | Olympiakos | 1 | 0 | Rubin | 23-02 | 20:05 | | Anderlecht | 0 | 1 | AZ Alkmaar | 23-02 | 20:05 | | At. Madrid | 1 | 0 | Lazio | 23-02 | 20:05 | | Schalke 04 | 3 | 1 | Plzen | 23-02 | 20:05 | | Besiktas | 0 | 1 | Sp. Braga | 23-02 | 20:05 | | Sporting | 1 | 0 | Légia Varsóvia | 23-02 | 20:05 | |
|
